The 12 Hallmarks of Aging in Dogs, Explained
Read full insightVitamin Antioxidants for Dogs
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References
Numbered references identify the sources used for specific claims. Read the study design, species and evidence boundaries alongside each finding.
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Jewell DE, Toll PW, Wedekind KJ, Zicker SC. Effect of increasing dietary antioxidants on concentrations of vitamin E and total alkenals in serum of dogs and cats. Evidence boundary: Six-week complete-food vitamin E study measuring blood vitamin E and lipid-oxidation products.↩ 1 · ↩ 2 · ↩ 3 · ↩ 4
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Hesta M, Ottermans C, Krammer-Lukas S, Zentek J, Hellweg P, Buyse J, Janssens GP. The effect of vitamin C supplementation in healthy dogs on antioxidative capacity and immune parameters. Evidence boundary: Fifteen-dog crossover study of added vitamin C under a high-vitamin-E background.↩
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Baskin CR, Hinchcliff KW, DiSilvestro RA, Reinhart GA, Hayek MG, Chew BP, Burr JR, Swenson RA. Effects of dietary antioxidant supplementation on oxidative damage and resistance to oxidative damage during prolonged exercise in sled dogs. Evidence boundary: Sled-dog antioxidant-blend study measuring oxidative biomarkers and laboratory resistance to oxidation.↩ 1 · ↩ 2
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Piercy RJ, Hinchcliff KW, DiSilvestro RA, Reinhart GA, Baskin CR, Hayek MG, Burr JR, Swenson RA. Effect of dietary supplements containing antioxidants on attenuation of muscle damage in exercising sled dogs. Evidence boundary: Separate 41-sled-dog study finding no attenuation of the CK muscle-injury response.↩ 1 · ↩ 2 · ↩ 3
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Heaton PR et al. Role of dietary antioxidants to protect against DNA damage in adult dogs. Evidence boundary: Forty-dog antioxidant-food study measuring DNA damage and vaccine-antibody responses.↩ 1 · ↩ 2
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Plevnik Kapun A, Salobir J, Levart A, Tavčar Kalcher G, Nemec Svete A, Kotnik T. Vitamin E supplementation in canine atopic dermatitis: improvement of clinical signs and effects on oxidative stress markers. Evidence boundary: Vitamin E as an adjunct to antihistamine treatment in 29 dogs with atopic dermatitis.↩ 1 · ↩ 2
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Jewell DE, Yu S, Joshi DK. Effects of serum vitamin E levels on skin vitamin E levels in dogs and cats. Evidence boundary: Study of dietary vitamin E and its concentrations in blood and skin.↩
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Zafalon RVA et al. Vitamin-mineral supplements do not guarantee the minimum recommendations and may imply risks of mercury poisoning in dogs and cats. Evidence boundary: Laboratory analysis of seven Brazilian vitamin-mineral products for homemade diets.↩
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Fletcher RS et al. Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells. Evidence boundary: Mouse and cell study of NR metabolism, used for normal NAD+ precursor biology.↩ 1 · ↩ 2 · ↩ 3
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Reactome. Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2. Evidence boundary: Curated normal mitochondrial electron transfer involving NADH and CoQ.↩ 1 · ↩ 2
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Reactome. glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+. Evidence boundary: Curated glutathione recycling reaction, including NADPH and the FAD-containing enzyme.↩ 1 · ↩ 2
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NIH Office of Dietary Supplements. Riboflavin: Fact Sheet for Health Professionals. Evidence boundary: Human nutrition guidance used for conserved riboflavin/cofactor biology, not pet doses.↩ 1 · ↩ 2 · ↩ 3 · ↩ 4
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Tanprasertsuk J; Tate DE; Shmalberg J. Roles of plant-based ingredients and phytonutrients in canine nutrition and health. Evidence boundary: Review distinguishing plant ingredients and phytonutrients in canine nutrition.↩ 1 · ↩ 2
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Hagen DM, Ekena JL, Geesaman BM, Viviano KR. Antioxidant supplementation during illness in dogs: effect on oxidative stress and outcome, an exploratory study. Evidence boundary: Exploratory antioxidant-combination study in systemically ill dogs; laboratory and clinical outcomes.↩
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