The 12 Hallmarks of Aging in Dogs, Explained
Read full insightVitamin B12 Supplement for Cats
By La Petite Labs Editorial 19 min read
References
Numbered references identify the sources used for specific claims. Read the study design, species and evidence boundaries alongside each finding.
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Reactome. MUT isomerises L-MM-CoA to SUCC-CoA. Species/context: Conserved mammalian chemistry; human curated pathwayEvidence boundary: This reaction explains a normal B12-dependent step in nutrient metabolism. It does not show that extra B12 increases energy in a cat already receiving enough.↩ 1 · ↩ 2 · ↩ 3
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Reactome. MTR transfers CH3 from MeCbl to HCYS. Species/context: Conserved mammalian chemistry; human curated pathwayEvidence boundary: B12 participates in methionine formation and folate recycling. These reactions help explain its importance to cell renewal; they do not establish that a supplement repairs age-related DNA damage.↩ 1 · ↩ 2 · ↩ 3
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Chee-Hoon Chang, Jonathan Lidbury, Jan S. Suchodolski, Joerg M. Steiner. Effect of oral or subcutaneous administration of cyanocobalamin in hypocobalaminemic cats with chronic gastrointestinal disease or exocrine pancreatic insufficiency. Species/context: CatsEvidence boundary: Both oral and injected cyanocobalamin corrected low blood B12 in this trial. The cats had gastrointestinal disease or pancreatic insufficiency, and the study did not test a daily multinutrient formula.↩ 1 · ↩ 2 · ↩ 3 · ↩ 4 · ↩ 5 · ↩ 6 · ↩ 7 · ↩ 8 · ↩ 9 · ↩ 10
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Peter H. Kook, Roger H. Melliger, Martin Hersberger. Efficacy of intramuscular hydroxocobalamin supplementation in cats with cobalamin deficiency and gastrointestinal disease. Species/context: CatsEvidence boundary: Hydroxocobalamin injections improved B12 and metabolic measurements in these 23 cats. There was no randomized comparison with other B12 forms, and the cats also received other treatments.↩ 1 · ↩ 2 · ↩ 3
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Craig G. Ruaux, Joerg M. Steiner, David A. Williams. Early biochemical and clinical responses to cobalamin supplementation in cats with signs of gastrointestinal disease and severe hypocobalaminemia. Species/context: CatsEvidence boundary: These 19 cats had severe B12 deficiency and intestinal signs. Their weight and biochemical changes after treatment do not predict what extra B12 will do for a healthy cat.↩
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Texas A&M Gastrointestinal Laboratory. Cobalamin Information. Species/context: Cats and dogs; feline recommendations usedEvidence boundary: The laboratory explains why B12 testing and follow-up matter in digestive disease. Treatment route and duration depend on the individual cat and the response to therapy.↩ 1 · ↩ 2 · ↩ 3 · ↩ 4 · ↩ 5
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Cornell Feline Health Center. Feeding Your Cat. Species/context: CatsEvidence boundary: A complete diet appropriate to life stage provides the nutritional foundation. A vitamin product alone cannot balance an improvised diet or replace food.↩
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La Petite Labs. Hollywood Elixir official ingredient panel. Species/context: Cats and dogsEvidence boundary: The current panel declares ingredient amounts per standard 2.5 g sachet. Hollywood Elixir supplies several complementary nutrients and is not the B12 treatment tested in the clinical studies.↩ 1 · ↩ 2 · ↩ 3 · ↩ 4 · ↩ 5
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Rachel S. Fletcher, Joanna Ratajczak, Craig L. Doig, Lucy A. Oakey, Rebecca Callingham, Gabriella Da Silva Xavier, Antje Garten, Yasir S. Elhassan, Philip Redpath, Marie E. Migaud, Andrew Philp, Charles Brenner, Carles Canto, Gareth G. Lavery. Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells. Species/context: Mouse skeletal-muscle cells and miceEvidence boundary: This work traces NR metabolism into NAD+. It explains the precursor pathway, rather than demonstrating a clinical benefit from a multinutrient formula in cats.↩ 1 · ↩ 2
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Reactome. Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2. Species/context: Conserved mitochondrial pathway; human curated recordEvidence boundary: This pathway describes normal electron transfer in mitochondria. It explains the relationship between NADH and CoQ10, rather than the effects of taking a supplement.↩ 1 · ↩ 2
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F. Watanabe, H. Katsura, S. Takenaka, T. Fujita, K. Abe, Y. Tamura, T. Nakatsuka, Y. Nakano. Pseudovitamin B12 is the predominant cobamide of an algal health food, spirulina tablets. Species/context: Spirulina tablet composition; no animals supplementedEvidence boundary: This analysis distinguished vitamin B12 from a related analogue in spirulina tablets. It was a composition study, not a measurement of B12 absorption or deficiency treatment in cats.↩
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La Petite Labs. Hollywood Elixir detailed ingredient list. Species/context: Cats and dogsEvidence boundary: The ingredient list identifies the B12 preparation and the forms of the other ingredients. A premix declaration should not be assumed to specify an equivalent amount of active vitamin for clinical treatment.↩ 1 · ↩ 2 · ↩ 3
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