Sirtuin Activators for Dogs: Boosting NAD+ for Longevity and Brain Health
Sirtuin Activation in Dogs: Supporting Longevity Through NAD+ and Polyphenols
Sirtuins are a family of proteins involved in cellular repair, stress response, inflammation control, and mitochondrial function. In dogs, as in humans, sirtuins are increasingly studied for their role in longevity and healthy aging. Supporting the activation of sirtuins may help maintain energy, mobility, and brain function into a dog’s senior years.
At La Petite Labs, we’ve formulated Hollywood Elixir™ with ingredients that naturally support sirtuin activation—including Nicotinamide Riboside (NR), Resveratrol, and Quercetin.
What Are Sirtuins, and Why Do They Matter for Dogs?
Sirtuins (SIRT1–SIRT7) are a group of enzymes that regulate critical processes like:
- Cellular repair and DNA stability
- Mitochondrial health and energy metabolism
- Inflammation response modulation
- Neuroprotection and brain aging resistance
In dogs, sirtuins help protect against the cellular effects of aging—especially in tissues like the heart, liver, brain, and muscles. Activating these enzymes may help delay age-related decline in mobility, cognition, and immune function.
How Do Sirtuins Work in the Body?
Sirtuins are NAD+-dependent enzymes, meaning they require NAD+ (Nicotinamide Adenine Dinucleotide) to function. As dogs age, their NAD+ levels drop—reducing sirtuin activity and increasing vulnerability to oxidative stress, inflammation, and DNA damage.
This makes NAD+ replenishment and polyphenol-based activation central to any canine longevity strategy.
Ingredients in Hollywood Elixir That Support Sirtuin Activity
Nicotinamide Riboside (NR)
NR is a cutting-edge NAD+ precursor that helps raise intracellular NAD+ levels, which in turn fuels SIRT1 and other sirtuins. This supports energy metabolism, DNA repair, and neuroprotective pathways in aging dogs.
Learn more about NR for dogs →
Resveratrol
Resveratrol is a polyphenol known to activate SIRT1 directly. In dogs, it has been studied for cardiovascular health, anti-inflammatory effects, and cellular defense against aging. It also acts synergistically with NAD+ boosters like NR.
Read about resveratrol for dogs →
Quercetin
Quercetin modulates sirtuin expression indirectly by reducing cellular senescence and oxidative stress. It helps maintain mitochondrial efficiency and has anti-inflammatory and neuroprotective benefits for senior dogs.
Signs Your Dog May Benefit From Sirtuin Support
- Slowing metabolism and energy loss
- Reduced mobility or joint stiffness
- Cognitive aging or disorientation
- Chronic low-grade inflammation or immune weakening
Supporting sirtuin pathways may offer holistic, multi-system benefits—especially for senior dogs who are beginning to show signs of aging.
Why Choose Hollywood Elixir?
- Combines NAD+ precursors, polyphenols, and adaptogens for layered longevity support
- Formulated with veterinary pharmacologists
- Powder format with no fillers or preservatives
- 3rd-party tested by NSF® laboratories
Result Timeline: What Pet Parents May Notice
- Week 1: Slight increase in alertness and appetite; improved response time
- Day 30: More consistent energy throughout the day, fewer signs of stiffness after rest
- Day 90: Clearer eyes, steadier gait, enhanced mood and connection, vitality reminiscent of earlier years
Sirtuin activity drops with age in dogs, contributing to fatigue, inflammation, and cognitive decline. Ingredients like Resveratrol and NR may help restore this protective system naturally.
Glossary
- Sirtuins: Enzymes that regulate aging, metabolism, and cellular health, fueled by NAD+.
- NAD+: A coenzyme critical for energy production and sirtuin function; declines with age.
- Resveratrol: A polyphenol that activates SIRT1 and reduces inflammation.
- Quercetin: An antioxidant flavonoid that protects mitochondria and modulates inflammation.
- Neuroprotection: The preservation of brain cells and cognitive health, especially in aging.
Frequently Asked Questions
Is it safe to give NAD+ boosters to dogs?
Yes, when using dog-appropriate forms like Nicotinamide Riboside at safe doses. Hollywood Elixir is formulated specifically for canine biology and tested for safety.
Can Sirtuin activators help with dog cognition?
Yes. Sirtuins, especially SIRT1, are involved in protecting neurons and supporting brain plasticity, which may help aging dogs stay mentally sharp.
What’s the difference between Resveratrol and Quercetin?
Both are polyphenols, but Resveratrol directly activates SIRT1 while Quercetin offers indirect support through antioxidant and mitochondrial benefits.
Do I need to give these daily?
Yes. Consistency is key to maintaining elevated NAD+ levels and sustaining long-term benefits from sirtuin support.
Can I mix this with food?
Absolutely. Hollywood Elixir is a fine powder designed to mix seamlessly into wet or dry food for maximum compliance and absorption.
