DoNotAge Pure Pet vs Hollywood Elixir® for Dogs

Compare the ingredients, research and daily cost of DoNotAge’s NMN chew and Hollywood Elixir’s 17-active formula.

By La Petite Labs Editorial 18 min read

Woman hugging a golden retriever while holding a Hollywood Elixir box

DoNotAge Pure Pet combines NMN and SIRT6 Activator with hyaluronic acid, MSM and boswellia. Hollywood Elixir combines NR and CoQ10 with glutathione, antioxidant vitamins and supporting nutrients. Understand the different jobs, the actual research and the cost for your dog's size.

Published by La Petite Labs, maker of Hollywood Elixir.

Two different selections for healthy-aging nutrition

DoNotAge Pure Pet for Dogs combines NMN and its seaweed-derived SIRT6 Activator with hyaluronic acid, MSM and boswellia. Hollywood Elixir combines NR and CoQ10 with glutathione, antioxidant vitamins and supporting nutrients. Both bring several ingredients together; their selections emphasize different jobs. 1 2

DoNotAge pairs an NAD+ starting material and a cellular-maintenance research target with joint-focused ingredients. Hollywood Elixir pairs ingredients used in cellular energy production with complementary antioxidant defenses. The practical difference also changes with dog size: DoNotAge's 30-chew jar lasts from 30 days down to 7.5 days at its published portions.

At a Glance

What does Hollywood Elixir add to this comparison?

Hollywood Elixir pairs NR and CoQ10 with glutathione, antioxidant vitamins and supporting nutrients for cellular-energy and antioxidant nutrition. Pure Pet pairs NMN and SIRT6 Activator with hyaluronic acid, MSM and boswellia. The meaningful choice is between these different ingredient selections, with serving size and purchase plan determining the cost.

Product
DoNotAge.org Pure Pet Supplement for Dogs
Category
NMN/SIRT6 and joint-ingredient dog supplement
Format
30 chews; one to four daily by published weight bands
Why owners notice it
A seaweed-derived SIRT6 ingredient and NMN alongside HA, MSM and boswellia.
What to check
Exact weight band, full recipe, acceptance, whole-pack cost and annual shipment commitment.
Side by Side

The Plain Comparison

Amounts are per Pure Pet dog chew and per full Hollywood Elixir sachet. Cost examples use the published daily portions and one-time USD pack prices before tax and shipping.

QuestionDoNotAge Pure Pet for DogsHollywood ElixirWhat that means
Ingredient selectionNMN, SIRT6 Activator, HA, MSM and boswellia: five quantified ingredients.17 actives, including NR, CoQ10, B vitamins, glutathione and antioxidant vitamins.Pure Pet emphasizes its NMN/SIRT6 and joint selection; Hollywood Elixir combines energy and antioxidant roles.
NAD+ starting material100 mg NMN per chew.60 mg NR tartrate per full sachet.Different materials; the weights do not rank canine response.
SIRT6 researchFucoidan identity; supplier-linked mouse preprint, not a finished dog-chew trial.No SIRT6 Activator declared.Credit the preclinical research without translating mouse lifespan to dogs.
Joint ingredients25 mg HA, 50 mg MSM and 50 mg boswellia per chew.No HA, MSM or boswellia declared.Pure Pet includes these joint-focused ingredients; the HA trial did not prove this chew relieves pain.
Energy and antioxidant selectionNMN; vitamin E listed without an amount.CoQ10 preparation 40 mg, reduced glutathione 50 mg, vitamin E 15 IU and vitamin C 10 mg, alongside NR.Hollywood Elixir brings specified energy-reaction and complementary antioxidant ingredients together.
Portion and format30 chews; one to four daily according to the printed kilogram bands.Powder for food; adult portions of half, one or two sachets by weight.Compare the amount the dog needs and will finish; check both complete recipes.
One-time 90-day cost20 lb: $94.50. 44 lb: $189. 110 lb: $378.20 lb: $199. 44 lb or 110 lb: $379.USD before tax/shipping. Pure Pet costs less in smaller examples; the 110 lb example is nearly equal.
Annual supply and qualityMatched annual options supply 360 days in one shipment; request a matching dog-lot quality report.Pack and subscription options differ; manufacturer batch quality summary available.Compare the actual offer and document scope, rather than treating every annual supply or certificate as equivalent.

Competitor label and pricing facts checked October 5, 2026. Sources are listed in the References section below.

Woman holding a Hollywood Elixir box beside a pug, a terrier and a food bowl

What is in the current Pure Pet dog chew?

Each chew declares 100 mg NMN, 130 mg SIRT6 Activator, 25 mg hyaluronic acid, 50 mg MSM and 50 mg boswellia. These are the dog amounts. DoNotAge's cat product has a separate, three-ingredient selection. 1

Vitamin E also appears among the dog's other ingredients, without a stated amount. Antioxidant nutrition is therefore not exclusive to Hollywood Elixir. Its difference is the particular combination of NR, CoQ10, reduced glutathione, antioxidant vitamins and supporting ingredients, with quantities specified per full sachet. 2

For a cat in the same household, our DoNotAge Pure Pet cat comparison covers the separate three-ingredient formula, feline research and current cat-chew offers.

Woman in sportswear holding a Hollywood Elixir box beside a black-and-tan dog outdoors

Match the portion to your dog before comparing jars

DoNotAge publishes four daily portions: one chew up to 10 kg; two at 11–26 kg; three at 27–45 kg; and four at 46 kg or more. A 30-chew jar lasts 30, 15, 10 or 7.5 days respectively. Its family feeding guide places the dog chews before breakfast. 1

Those printed bands leave fractional gaps, such as 10.5 kg. Ask DoNotAge to confirm the portion if your dog's precise weight falls between them.

Hollywood Elixir's adult directions are half a sachet below 7 lb, one from 7–30 lb, and two above 30 lb. One full sachet is 2.5 g. 3

Woman holding a Hollywood Elixir box above her forehead beside a Bernese mountain dog outdoors

A chew and a powder bring different feeding tasks

A chew needs to suit the dog's willingness and ability to eat it. One visible DoNotAge reviewer described breaking chews for an older pug with few teeth. That illustrates a practical feeding question: can your dog comfortably eat the full serving? Hollywood Elixir is a powder served with food. 1 3

Read the whole recipe too. Pure Pet lists sweet potato flour, pea starch, chicken, vegetable glycerin, calcium carbonate, dried brewers yeast, dried tomato, natural smoked flavor, vitamin E and rosemary extract. Hollywood Elixir contains whey protein isolate and chicken flavor/chicken liver, plus yeast extract, glycine and hydroxypropyl beta-cyclodextrin. 1 2

Golden retriever nuzzling a woman holding a Hollywood Elixir box on the grass beside a food bowl

What 90 days costs at three dog sizes

Using the $31.50 Pure Pet jar and Hollywood Elixir's $199/90-sachet or $379/180-sachet packs, these one-time purchases cover exactly 90 days. All prices are USD before tax and shipping. 1 3

  • 20 lb dog, about 9.1 kg: one Pure Pet chew daily means three jars, $94.50, or $1.05 a day. One Hollywood Elixir sachet daily costs $199, about $2.21 a day.
  • 44 lb dog, about 20 kg: two chews daily mean six jars, $189, or $2.10 a day. Two sachets daily cost $379, about $4.21 a day.
  • 110 lb dog, about 49.9 kg: four chews daily mean twelve jars, $378, or $4.20 a day. Two sachets daily cost $379, about $4.21 a day.

For that 110 lb dog, $1 more across 90 days brings Hollywood Elixir's NR, CoQ10, glutathione and antioxidant-vitamin selection. DoNotAge costs less in the two smaller examples. Annual subscriptions are a separate comparison below.

“NAD+ helps cells use the energy in food. SIRT6 uses NAD+ in cellular maintenance and DNA-repair processes.”

NAD+ and SIRT6 do different work in a cell

Food supplies the fuel. As nutrients are broken down, NAD+ accepts electrons and becomes NADH. Those electrons can enter reactions in mitochondria that help produce ATP, the molecule supplying energy for much of the cell's work. NMN and NR are different starting materials related to NAD+ production. 4 5

SIRT6 is a protein that uses NAD+ while participating in cellular maintenance, including DNA-repair processes. Supplying an NAD+ starting material and studying an ingredient for SIRT6 activation address different steps in related biology. 9 Our NAD+ for dogs guide explains the coenzyme behind both ideas.

Overhead view of a black-and-white dog beside a food bowl and Hollywood Elixir box

What does SIRT6 Activator mean?

DoNotAge identifies its SIRT6 Activator as fucoidan from the brown seaweed Fucus vesiculosus. Laboratory research found that fucoidan could activate the SIRT6 enzyme. That explains the name and the research interest. 8 9

There is also relevant supplier-linked animal research: a 2025 preprint used fucoidan supplied by DoNotAge.org in an aging study of 80 mice. Male median lifespan increased significantly; the female lifespan difference was not significant. Frailty measures improved in both sexes. A coauthor disclosed membership of DoNotAge's scientific advisory board. 10

This gives the ingredient a real preclinical research story. The study remains a preprint, and it tested fucoidan in mice, not the mixed dog chew or a dog's lifespan.

Woman smiling beside a golden retriever, a green food bowl and a Hollywood Elixir box

Hollywood Elixir connects an NAD+ building block with energy ingredients

Hollywood Elixir uses nicotinamide riboside, declared as 60 mg NR tartrate per full sachet. Comparing that weight with Pure Pet's 100 mg NMN cannot tell you which serving would raise a dog's NAD+ more: they are different materials, and the finished regimens have not been compared here. 1 2

The companion ingredients give Hollywood Elixir a distinct purpose. CoQ10 carries electrons within the machinery producing ATP; vitamin B2 supplies coenzymes used in energy production and metabolism. Each sachet declares 40 mg of its 98% CoQ10 preparation and 0.5 mg B2, alongside NR. 2 5 16

Man holding a Hollywood Elixir box while sitting on an outdoor sofa with a golden retriever

Glutathione and vitamins protect in complementary ways

Reduced glutathione helps an enzyme turn hydrogen peroxide into water. Vitamin E helps interrupt damaging oxidation in membrane fats. Vitamin C can help regenerate vitamin E after it has acted as an antioxidant. Together, these explain several distinct jobs within cellular protection. 6 7

Hollywood Elixir supplies 50 mg reduced glutathione, a vitamin E preparation providing 15 IU, and 10 mg vitamin C per full sachet. Pure Pet also lists vitamin E; Hollywood Elixir's distinction is its declared glutathione-and-vitamin combination alongside the energy ingredients. 1 2

Why those jobs belong in one daily system

Cells make usable energy and maintain protective defenses in the same living tissue. Hollywood Elixir brings ingredients for those related needs together: NR, CoQ10 and B2 alongside glutathione and antioxidant vitamins.

The rest of its 17-active selection includes niacin, B6 and a B12 preparation; resveratrol, quercetin, blueberry and a 2% astaxanthin preparation; and yeast beta-glucans, reishi, spirulina and whey protein isolate. 2 The full ingredient declaration lists their forms and amounts. Those preparation details matter: a weight declared for a dilute vitamin or botanical preparation is not automatically the weight of its pure active constituent.

“CoQ10 helps cells make usable energy. Glutathione helps remove hydrogen peroxide, while vitamin E helps protect membrane fats.”

Spotted gray dog beside a Hollywood Elixir box held in a person's hand

How strong is the joint-ingredient case?

Hyaluronic acid is naturally present in joint fluid and contributes to its lubricating, shock-absorbing properties. Pure Pet combines HA with MSM and boswellia, making joint-related nutrition a clear part of its ingredient selection. 1 11

Direct dog research deserves a careful reading. A 2021 trial assigned 55 dogs after cruciate surgery to an oral HA-rich rooster-comb preparation or placebo for ten weeks. Both groups improved, with no significant difference between groups in clinical pain or lameness. Joint-fluid HA rose and PON-1 fell from baseline in the HA group, but neither marker differed significantly between groups. The ingredient supplier funded the trial; it was not a Pure Pet study. 11

That evidence does not establish pain relief from this chew. Owners comparing other joint-ingredient combinations can also read our Renue dog-chew comparison, which covers its glucosamine/chondroitin selection.

Golden retriever nuzzling a man holding a Hollywood Elixir box beside a food bowl

What canine NMN research actually tells us

A small 2020 study gave NMN or water to ten beagles for 14 days. It found changes in blood nicotinamide and kidney-related laboratory markers. It was a short metabolism and safety study, not a demonstration of better everyday activity or longer life. 12

A 2026 report followed eight dogs with elevated NT-proBNP, a heart-related marker. It was an uncontrolled case series, with varied illnesses and other medication in severe cases. Changes during follow-up cannot establish that NMN caused a clinical benefit. 13

Neither study tested Pure Pet. The research reviewed here does not establish longer life from either finished formula, or a clinical advantage of one over the other.

Golden spaniel eating from a green bowl beside a Hollywood Elixir box

What does a supplement add to complete food?

A complete-and-balanced food is intended to provide the essential nutrition for its stated life stage. Choosing an optional supplement does not mean that your dog's usual food is deficient. 15

The additional purchase is a selected formulation. Hollywood Elixir combines an NAD+ precursor, CoQ10 and complementary antioxidant ingredients in measured daily portions. Pure Pet combines its NMN/SIRT6 approach with HA, MSM and boswellia. Compare those additions with the food and other supplements already in the routine; counting every vitamin already present is more useful than assuming that more is always better.

An annual shipment supplies 360 days at the matching portion

DoNotAge's annual options contain 12, 24, 36 or 48 jars for $300, $600, $900 or $1,200 respectively. At one, two, three or four chews a day, each matched option supplies 360 days, because every jar contains 30 chews. The order arrives as one annual shipment. 1

For example, the four-chew option costs $1,200 for 1,440 chews: about $3.33 per day. That is below its $4.20 one-time daily cost, so the earlier near-price comparison does not apply to this annual offer. Decide whether the portion, acceptance and storage commitment suit your household before choosing that quantity.

Read the quality document for the actual product

DoNotAge describes a quality guarantee and GMP/ISO 9001 manufacturing standards. These explain its stated program; the captured dog product page did not link a readable finished dog-lot report. Ask for a record matching the product and batch you intend to buy. 1

Hollywood Elixir's COA lookup provides batch quality information. The reviewed record is a manufacturer-issued quality summary that identifies the lot and shows the methods and statuses for its individual checks. 14 For either product, the useful details are the sample identity, lot, issuer, measured result and test method.

Woman holding a Hollywood Elixir box beside a dapple dachshund and green food bowl on a sofa

Keep the daily routine easy to describe

Before adding anything, note the things that brought you to the comparison: finishing breakfast, willingness to start the usual walk, getting up from a familiar resting place. Then record whether the intended supplement serving was actually eaten, alongside other changes in food or routine.

A brief record gives you something more concrete than “seems younger.” It does not identify which ingredient caused a change. New pain, limping or a clear change in activity belongs in a veterinary conversation; the supplement decision can then fit the dog's existing care.

Woman cuddling a brown-and-white spaniel while holding a Hollywood Elixir box

Choose the selection that matches the purchase

Pure Pet offers NMN, a SIRT6-targeting ingredient and a joint-focused combination. It costs less for the smaller dogs in our examples, and its annual option changes the budget further.

Hollywood Elixir brings NR and CoQ10 for cellular-energy nutrition together with glutathione and antioxidant vitamins for cell protection. At the 110 lb example's one-time prices, that combined selection costs just $1 more over 90 days. For smaller dogs, it is a more substantial premium for those different ingredient jobs. The Hollywood Elixir guide brings the full system and daily routine together.

Bring energy and antioxidant nutrition into the daily bowl

Choose Hollywood Elixir's 17-active system to pair an NAD+ building block and cellular-energy ingredients with complementary antioxidant defenses. Bring NR and CoQ10 for cellular energy together with glutathione and antioxidant vitamins for cell protection in your dog’s regular meal.

Explore the full Hollywood Elixir formula and packs, then select the portion for your adult dog's weight. Review the complete recipe alongside the food and care already in place, and make the serving part of a meal your dog finishes.

“Hollywood Elixir brings NR and CoQ10 together with glutathione, antioxidant vitamins and supporting nutrients for daily cellular-energy and antioxidant nutrition.”

Educational content only. This material is not a substitute for veterinary advice. Always consult your veterinarian about your dog’s specific needs. These statements have not been evaluated by the Food and Drug Administration. Products mentioned are not intended to diagnose, treat, cure, or prevent any disease.

Glossary

NAD+: a coenzyme involved in reactions that help cells use energy from food and in other cellular processes.

NMN and NR: different starting materials related to NAD+ production.

ATP: a molecule supplying energy for much of a cell's work.

SIRT6: a protein that uses NAD+ and participates in cellular maintenance, including DNA-repair processes.

Fucoidan: a group of compounds found in brown seaweeds; preparation matters when comparing studies.

Hyaluronic acid: a substance present in joint fluid and other tissues. Its natural role does not by itself establish an oral supplement outcome.

COA: certificate of analysis; read for the actual sample, lot, issuer and test methods.

Related Reading

Aging & Senior Dog Guidance
• Dog Age Calculator
• Dog Lifespan by Breed
• Dog Dementia
• Lethargy in Dogs
• My Dog Won't Eat
• Dog Pacing At Night
• Dog Licking Paws
• Can Dogs Dehydrate

Healthy Aging Support
• NAD+ for Dogs
• NMN for Dogs
• Antioxidants Supplements for Dogs
• Best Senior Dog Supplements & Vitamins
• Rapamycin for Dogs

References

Product facts, public claims, ingredient details, and quality-language checks were checked against the references below.

  1. Brand source Pure Pet Supplement for Dogs: current formula, directions and offers Current dog product declaration, printed portions and offers; owner experiences are not clinical evidence.
  2. Brand source La Petite Labs: Hollywood Elixir ingredient declaration Current Hollywood Elixir ingredient declaration and preparations per full sachet.
  3. Brand source La Petite Labs: Hollywood Elixir product and commerce Hollywood Elixir adult portions, pack prices and use with food.
  4. Institutional source NIH Office of Dietary Supplements: Niacin Normal niacin/NAD biology, not a canine product trial.
  5. Institutional source Reactome: NADH and CoQ electron transfer Normal mitochondrial electron-transfer pathway, not a retail-formula trial.
  6. Institutional source Reactome: glutathione helps remove hydrogen peroxide Normal glutathione-dependent peroxide removal, not proof of a supplement outcome.
  7. Institutional source Vitamin E: antioxidant function Vitamin E function and regeneration by vitamin C; conserved biology only.
  8. Brand source SIRT6 Activator: fucoidan identity Manufacturer identity of the SIRT6 ingredient, not a dog absorption or efficacy study.
  9. Research source The Identification of a SIRT6 Activator from Brown Algae Fucus distichus Laboratory enzyme study, not oral dog supplementation.
  10. Brand source SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice Mouse preprint using DoNotAge-supplied fucoidan; not the mixed dog chew or canine lifespan.
  11. Research source Effects of Oral Hyaluronic Acid Administration in Dogs Following Tibial Tuberosity Advancement Surgery for Cranial Cruciate Ligament Injury Different HA-rich preparation after canine cruciate surgery; no between-group clinical pain/lameness advantage.
  12. Research source Subacute Toxicity Study of Nicotinamide Mononucleotide via Oral Administration Small, short canine metabolism/toxicology study, not finished-formula efficacy or lifetime safety.
  13. Research source Exploring the therapeutic potential of NMN in regulating canine NT-proBNP levels Uncontrolled heterogeneous eight-dog case series, with concurrent medication in severe cases.
  14. Brand source La Petite Labs: Hollywood Elixir guide and COA Lookup Manufacturer guide and batch quality summary, not independent assays of every active.
  15. Institutional source Complete and Balanced Pet Food Meaning of complete-and-balanced food; no assumed need for either supplement.
  16. Institutional source Riboflavin: normal coenzyme roles Normal riboflavin coenzyme functions, not a dog product trial.

FAQ

What is in DoNotAge Pure Pet for Dogs?

Each chew declares 100 mg NMN, 130 mg SIRT6 Activator, 25 mg hyaluronic acid, 50 mg MSM and 50 mg boswellia. Vitamin E appears in the other-ingredient list without a stated amount. The dog formula is different from the cat product.

What is SIRT6 Activator?

DoNotAge identifies it as fucoidan from Fucus vesiculosus, a brown seaweed. SIRT6 is a protein that uses NAD+ in cellular maintenance, including DNA-repair processes. Laboratory activation of that protein is different from proving an outcome in a dog taking the finished chew.

Has Pure Pet been shown to extend a dog’s life?

The reviewed sources do not establish that result. A preprint using DoNotAge-supplied fucoidan reported a significant male lifespan increase and lower frailty measures in mice. It did not test the mixed Pure Pet chew or dog lifespan.

How many Pure Pet dog chews are given daily?

The published bands are one chew up to 10 kg, two at 11–26 kg, three at 27–45 kg, and four at 46 kg or more. These printed bands leave fractional gaps; ask DoNotAge to confirm the portion if your dog’s exact weight falls between bands.

How long does a 30-chew jar last?

At one, two, three or four chews daily, it lasts 30, 15, 10 or 7.5 days respectively. A single jar is therefore not a month’s supply for every dog.

Does the hyaluronic acid research prove joint relief from Pure Pet?

No. The dog trial discussed here used a different HA-rich preparation after cruciate surgery. Both treatment and placebo groups improved, without a significant difference in clinical pain or lameness. Pure Pet also contains MSM and boswellia, but that trial did not test its combined formula.

Is 100 mg NMN stronger than 60 mg NR tartrate?

Those weights describe different materials and do not establish equivalent absorption, a dog’s NAD+ response or clinical strength. Hollywood Elixir’s 60 mg NR tartrate is declared per full sachet; its CoQ10, glutathione and companion ingredients are separate reasons to compare the formulation.

Which supplement costs less?

For 90 days at the one-time USD prices and published portions, a 20 lb dog costs $94.50 with Pure Pet versus $199 with Hollywood Elixir; a 44 lb dog costs $189 versus $379; a 110 lb dog costs $378 versus $379. Tax and shipping are excluded. The near-price result is specific to the 110 lb example and those one-time offers.

How does the annual Pure Pet subscription work?

The matched options are 12, 24, 36 or 48 jars for $300, $600, $900 or $1,200, sent as one annual shipment. At the corresponding one-to-four-chew daily portions, each supplies 360 days, not 365. Its discounted cost should be considered separately from one-time jar prices.

What matters about the complete recipe and feeding format?

Pure Pet is a chew containing chicken and other carrier ingredients; Hollywood Elixir is a powder for food containing chicken flavor/chicken liver and whey protein isolate. Check the full recipe against existing dietary needs and count only the serving your dog actually finishes. A complete-and-balanced food remains the nutritional foundation.

Dalmatian looking toward a Hollywood Elixir box held in a person's hand

Discover LPL-01: How This Fits Into a Larger Canine Longevity System

Aging in dogs is not driven by a single pathway. It’s the result of interacting biological systems—energy metabolism, oxidative stress, immune signaling, and structural integrity—changing over time.

This article explores one piece of that puzzle. If you want to understand how these pieces connect—and what actually moves the needle—you need to zoom out.

Start with the underlying science: