Anti-Aging Pill for Dogs

The pill in the headlines, the pills on store shelves, and how to tell them apart.

By La Petite Labs Editorial 7 min read

As Seen On

Woman hugging a golden retriever while holding a Hollywood Elixir box
Contents

There's no approved anti-aging pill for dogs yet. The one in the headlines is LOY-002, a daily pill from the veterinary biotech company Loyal for dogs aged 10 and older. It's still in FDA review and can't be bought anywhere. Loyal expects the last section of its application to be reviewed in 2027. The "anti-aging" pills and chews you can buy today are supplements: they aren't drugs, and none has been shown to help dogs live longer.

Here's what's coming and when, and how to judge what's already on the shelf.

La Petite Labs publishes this guide and makes Hollywood Elixir, a dog supplement. We're not affiliated with Loyal.

Is there an anti-aging pill for dogs?

Not an approved one. No drug has been approved to slow aging or extend lifespan in dogs.1 Several are in development, and one, LOY-002, is close enough to approval that it regularly makes the news. Everything sold today as an "anti-aging pill" for dogs is a supplement.

Anti-Aging Pill for Dogs at a glance

Is there an approved one?
No. No drug is approved to slow aging or extend lifespan in dogs
The pill in the news
LOY-002 from Loyal, for dogs 10+ weighing 14–179 lb
Release date
Not confirmed; Loyal expects the manufacturing review in 2027
Price
Not published; one media report says around $100 a month, unconfirmed
Other pills in development
LOY-003 for large dogs; rapamycin in the TRIAD trial
On sale today
Supplements. None has been shown to extend lifespan
What works today
Keeping your dog lean, with regular vet check-ups

Anti-aging drugs vs supplements

Longevity drug (such as LOY-002)Anti-aging supplement
FDA review before saleYes: safety, manufacturing and expected effectivenessNo
What it aims to doChange the biology of agingAdd nutrients to the diet
How you get itVet's prescription, once approvedSold freely
Lifespan evidenceBeing tested: STAY follows about 1,300 dogsNone that we're aware of
Available now?NoYes

Competitor label and pricing facts checked November 10, 2026. Sources are listed in the References section below.

Woman holding a Hollywood Elixir box beside a pug, a terrier and a food bowl

What is the anti-aging pill for dogs in the news?

It's almost always LOY-002, from Loyal, a San Francisco company that develops drugs to extend healthy lifespan in dogs. LOY-002 is a once-daily pill for dogs 10 and older, weighing 14 to 179 lb. It aims to improve insulin sensitivity, meaning how readily the body responds to insulin, which tends to fall with age.1

It's being tested in STAY, a study of about 1,300 senior dogs at more than 70 US vet clinics. Each dog gets either LOY-002 or a look-alike placebo, and neither owners nor vets know which.2 Read our full LOY-002 guide.

Woman in sportswear holding a Hollywood Elixir box beside a black-and-tan dog outdoors

When will the dog anti-aging pill be available?

There's no confirmed date. The FDA has accepted two of the three main sections of LOY-002's application: effectiveness and safety. Loyal planned to submit the third, manufacturing, in 2026, and expects the FDA to review it in 2027.34 A launch would then depend on the FDA granting conditional approval, which isn't guaranteed. On that timeline, 2027 is the earliest realistic year, not a promise.

Woman holding a Hollywood Elixir box above her forehead beside a Bernese mountain dog outdoors

How much will the anti-aging pill cost?

Loyal hasn't published a price. Entrepreneur has reported an expected price of around $100 a month for LOY-002, but Loyal hasn't confirmed it.5 As a prescription drug, it would also mean a vet visit to start and whatever check-ups your vet recommends.

Golden retriever nuzzling a woman holding a Hollywood Elixir box on the grass beside a food bowl

Can I buy an anti-aging pill for my dog online?

Not the one in the news. LOY-002 isn't approved, so it can't be legally sold, and there are no authorized sellers.1 When it launches, it will be prescription-only, through vets. What you'll find online under "anti-aging pill for dogs" are supplements, sometimes marketed in the same language as the drug.

There's no approved anti-aging pill for dogs yet. The one in the news is LOY-002.

What other anti-aging pills are in development?

Two more pills are in serious development:

  • LOY-003, Loyal's daily pill for large dogs. It lowers growth hormone and IGF-1, which big dogs tend to have more of. The FDA accepted its effectiveness section in September 2026.6 LOY-003 guide
  • Rapamycin, a human transplant drug, given as a weekly pill in TRIAD, the Dog Aging Project's 580-dog trial.7 Rapamycin for dogs

Loyal also has an injection for large dogs, LOY-001. Our dog longevity drugs guide compares all four.

Overhead view of a black-and-white dog beside a food bowl and Hollywood Elixir box

Which dogs would these pills be for?

Each one targets a different group:

  • LOY-002: dogs 10 and older, 14 to 179 lb.1
  • LOY-003: large dogs. Loyal's overview says 5 and older and at least 60 lb; its FAQ says 7 and older and at least 40 lb.1 Check whether your dog qualifies.
  • Rapamycin in TRIAD: dogs 7 and older, 44 to 121 lb, and only within the trial.7

Loyal says that if its drugs are approved, they'll be labeled for the same kinds of dogs studied in their main trials.1

Woman smiling beside a golden retriever, a green food bowl and a Hollywood Elixir box

How would an anti-aging pill work?

Not by treating one disease. These drugs aim at processes thought to drive aging itself:

  • LOY-002 targets metabolism, aiming to lower the high insulin levels that tend to come with age.1
  • LOY-003 lowers growth hormone and IGF-1, hormones Loyal links to big dogs' shorter lives.6
  • Rapamycin dampens mTOR, a hub inside cells that controls growth. In lab mice it has extended lifespan.7

Whether any of these adds healthy years in pet dogs is exactly what the trials are testing.

Man holding a Hollywood Elixir box while sitting on an outdoor sofa with a golden retriever

Is an anti-aging pill safe for dogs?

It depends on the drug, and the full answer isn't public yet. The FDA has accepted LOY-002's safety section, which Loyal says included field data from 400 dogs in STAY.1 Safety data for LOY-003 is still being gathered.8 Rapamycin suppresses the immune system at the higher amounts used in transplant patients, and the Dog Aging Project says it can't recommend it for aging outside its trial.9 The side-effect details for any approved pill will be on its label.

What are the anti-aging pills you can buy today?

They're supplements: capsules, chews, powders and drops sold for "healthy aging" or "longevity". Common ingredients include NAD+ precursors such as nicotinamide riboside (NR) and NMN, antioxidants, omega-3 fatty acids and medicinal mushrooms.

In the US, pet supplements aren't a separate legal category the way human dietary supplements are. The FDA regulates them as animal food or as drugs, depending on what they contain and what they claim.10 No FDA approval stands behind a supplement's anti-aging claim.

No supplement has been shown to make dogs live longer.

Spotted gray dog beside a Hollywood Elixir box held in a person's hand

Do anti-aging supplements for dogs work?

None has been shown to make dogs live longer. Some ingredients have small dog studies behind them, usually measuring one specific thing over weeks or months. The best-designed so far, a 2024 randomized trial in senior dogs, measured owner-rated thinking and memory, not lifespan.11

That kind of result can be useful. It isn't lifespan evidence, and a study of one ingredient or blend doesn't tell you what a different product does. For NAD+ supplements, our NAD+ for dogs guide goes through every dog study we could find.

Golden retriever nuzzling a man holding a Hollywood Elixir box beside a food bowl

How to read an anti-aging supplement label

A good label lets you and your vet see exactly what your dog would get:

  • Every active ingredient with its amount. A "proprietary blend" with one total weight hides how much of each ingredient is in it.
  • A serving matched to your dog's weight, not one size for every dog.
  • Batch testing you can check, such as a certificate of analysis for the batch you bought.
  • Claims that stay in bounds. "Supports healthy aging" is a nutrition claim. "Adds years" or "reverses aging" is a claim no supplement has the evidence for.
Golden spaniel eating from a green bowl beside a Hollywood Elixir box

Anti-aging claims to be wary of

  • "Clinically proven to extend life." No dog supplement has shown that.
  • "FDA-approved." The FDA doesn't approve pet supplements.10
  • "Works like the Loyal pill" or "a natural LOY-002." Loyal hasn't disclosed LOY-002's active ingredient, so no supplement can claim to match it.1
  • "The same anti-aging formula people take." Human products can contain ingredients that are dangerous to dogs, such as the sweetener xylitol, and their amounts are set for people.14

Supplement or drug: what's the difference?

  • Approval: a drug must satisfy the FDA on safety, manufacturing and expected effectiveness before it's sold.12 A supplement doesn't go through that review.10
  • Purpose: a longevity drug aims to change the biology of aging. A supplement adds nutrients to the diet.
  • Access: the drugs will need a vet's prescription. Supplements are sold freely.
  • Evidence: LOY-002 is in a 1,300-dog placebo-controlled trial that measures lifespan.2 We're not aware of any dog supplement that has been tested that way.

Should I wait for the pill or start a supplement now?

It doesn't have to be one or the other. The pill, if it's approved, is at least a year away, and it would be for a specific group of dogs. In the meantime, the basics matter most, and a supplement is an optional extra on top of them. If your dog later starts a prescription drug, give your vet the full list of supplements they take so it can be checked.

Woman holding a Hollywood Elixir box beside a dapple dachshund and green food bowl on a sofa

What you can do for your dog now

  • Keep your dog lean. In a lifelong study of 48 Labradors, dogs fed 25% less than their littermates lived a median of 1.8 years longer.13 Ask your vet for a target weight before cutting a senior dog's food.
  • Keep up regular check-ups, so problems are found early.
  • Keep them moving, with exercise suited to their age.
  • Feed a complete and balanced diet, with treats kept to a small share of the day.

Our guide to diet and dog longevity goes further.

Woman cuddling a brown-and-white spaniel while holding a Hollywood Elixir box

What to ask your vet

  • Is my dog likely to be a candidate for LOY-002 or LOY-003 if they're approved?
  • Is my dog at a healthy weight, and what should the target be?
  • Would a supplement add anything to my dog's current diet?
  • Does anything my dog already takes rule out a particular supplement?

Where Hollywood Elixir fits

We make Hollywood Elixir, a daily nutrition powder for adult and senior dogs. It's built around nicotinamide riboside, an NAD+ precursor, with CoQ10, glutathione and 14 more actives, and every active amount is printed on the label. It's a supplement, not an anti-aging drug: it isn't designed to do what LOY-002 is being tested for, and it hasn't been tested for lifespan. Its case is practical: one daily sachet stirred into food instead of a cupboard of separate supplements, with the serving set by your dog's weight and batch results you can look up. If that suits your dog, talk it over with your vet. See the full formula and serving guide.

The best-supported anti-aging step today is keeping your dog lean.

Educational content only. This material is not a substitute for veterinary advice. Always consult your veterinarian about your dog’s specific needs. These statements have not been evaluated by the Food and Drug Administration. Products mentioned are not intended to diagnose, treat, cure, or prevent any disease.

Glossary

Anti-aging pill: an informal name used for both investigational longevity drugs and healthy-aging supplements.

Longevity drug: a medicine developed to extend healthy lifespan, reviewed by the FDA before it can be sold.

Supplement: a product that adds nutrients or other ingredients to a dog's diet; the FDA regulates pet supplements as food or drugs.

RXE: reasonable expectation of effectiveness, the FDA's preliminary effectiveness standard.

Conditional approval: FDA permission to sell an animal drug for up to five years while full effectiveness evidence is gathered.

Proprietary blend: a group of ingredients listed with one total weight, so the amount of each isn't shown.

Related Reading

Aging & Senior Dog Guidance
• Dog Age Calculator
• Dog Lifespan by Breed
• Dog Dementia
• Lethargy in Dogs
• My Dog Won't Eat
• Dog Pacing At Night
• Dog Licking Paws
• Can Dogs Dehydrate

Healthy Aging Support
• NAD+ for Dogs
• NMN for Dogs
• Antioxidants Supplements for Dogs
• Best Senior Dog Supplements & Vitamins
• Dog Longevity Drugs
• Rapamycin for Dogs

References

Sources and further detail

  1. Loyal, *For veterinarians* (program status, eligibility and safety; checked November 2026)
  2. Loyal, *Clinical trials* (STAY design and enrollment)
  3. dvm360 (13 Jan 2026), Lifespan extension drug in development for senior dogs reaches a new milestone
  4. Loyal (11 Feb 2026), Loyal raises $100M Series C, led by age1, to advance the first canine longevity drug
  5. Entrepreneur, This $100-a-month pill can extend the life of your dog
  6. Loyal (16 Sept 2026), Longer lives for bigger dogs? Loyal earns third RXE acceptance from the FDA
  7. Coleman AE et al. *GeroScience* (2025). Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale
  8. Loyal (Feb 2025), Product brief for veterinarians (v6)
  9. Dog Aging Project, *Can I give my dog rapamycin on my own?*
  10. FDA, *FDA's regulation of pet food*
  11. Simon KE et al. *Scientific Reports* (2024). Senolytic and NAD+ precursor combination in senior dogs
  12. FDA, *Conditional approval explained: a resource for veterinarians*
  13. Kealy RD, Lawler DF, Ballam JM et al. *JAVMA* (2002). Effects of diet restriction on life span and age-related changes in dogs
  14. FDA, *Paws off xylitol; it's dangerous for dogs*

FAQ

Is there an FDA-approved anti-aging pill for dogs?

No. LOY-002, the pill in the news, has two of its three main FDA sections accepted, with the manufacturing review expected in 2027. It would then need conditional approval before it could be sold.

What is the new anti-aging pill for dogs?

It's LOY-002, a once-daily pill from Loyal for dogs 10 and older weighing 14 to 179 lb. It aims to improve insulin sensitivity, and it's being tested in a 1,300-dog study called STAY.

When will the anti-aging pill for dogs be available?

No release date is confirmed. Loyal expects the FDA to review LOY-002's manufacturing section in 2027, and a launch would depend on conditional approval after that.

How much does the dog anti-aging pill cost?

Loyal hasn't published a price. Entrepreneur has reported around $100 a month, but Loyal hasn't confirmed it. Vet visits would add to the cost.

Do anti-aging supplements make dogs live longer?

None has been shown to. Some ingredients have small dog studies on specific measures, such as owner-rated thinking and memory, but none has measured lifespan.

Are anti-aging supplements safe for dogs?

It depends on the product. Choose one made for dogs, with every ingredient amount on the label and a serving set by weight, and check with your vet if your dog has a health condition or takes medicines.

Can I give my dog a human anti-aging supplement?

Not without your vet's advice. Human products can contain ingredients that are dangerous to dogs, such as the sweetener xylitol, and their amounts are set for people.

What's the difference between LOY-002 and LOY-003?

LOY-002 is a daily pill for senior dogs that targets insulin. LOY-003 is a daily pill for large dogs that lowers growth hormone and IGF-1.

Is there an anti-aging pill for cats?

No drug has been approved for that, and Loyal's programs are all for dogs. See our guide to longevity drugs for cats.

Dalmatian looking toward a Hollywood Elixir box held in a person's hand

Discover LPL-01: How This Fits Into a Larger Canine Longevity System

Aging in dogs is not driven by a single pathway. It’s the result of interacting biological systems—energy metabolism, oxidative stress, immune signaling, and structural integrity—changing over time.

This article explores one piece of that puzzle. If you want to understand how these pieces connect—and what actually moves the needle—you need to zoom out.

Start with the underlying science: