Because canine-specific NMN data is still developing, day-to-day tolerance monitoring is a key safety tool. Start with a simple baseline for 7–14 days (appetite, stool quality, vomiting frequency if any, energy/behavior patterns), then compare after introducing NMN.
What to watch most closely:
- Stool changes: softer stools, diarrhea, mucus, straining, or new urgency.
- Vomiting or nausea signs: lip-licking, drooling, repeated swallowing, reduced interest in food.
- Appetite changes: skipping meals, slower eating, or sudden food refusal.
- Behavior changes: restlessness, unusual lethargy, agitation, or sleep disruption.
Stop-and-call-vet triggers:
- Repeated vomiting, persistent diarrhea, or any blood in vomit/stool.
- Marked appetite loss lasting more than a day, especially in small dogs or dogs with other illnesses.
- New weakness, collapse, severe lethargy, or signs of pain.
- Any rapid change in drinking/urination patterns or jaundice (yellowing of gums/eyes).
If mild GI effects occur, don’t “push through” by adding multiple new products at once; simplify and reassess with your veterinarian.