The most common rimadyl side effects dogs experience involve the gastrointestinal tract: decreased appetite, nausea, vomiting, soft stool, or diarrhea. These signs can happen early in a course or after a period of doing well, especially if a dog becomes stressed, changes food, or gets mildly dehydrated. Some dogs also seem “off” in a nonspecific way—quieter, less social, or less interested in treats. These are not rare, and they are a major reason vets emphasize watching the dog, not just the calendar.
OWNER CHECKLIST: watch for (1) skipped meals or slower eating, (2) lip-licking or swallowing like nausea, (3) new gassiness or belly tenderness, (4) soft stool that persists beyond a day, and (5) vomiting even once if it is unusual for that dog. Write down when signs started and whether the dose was given with food. If any sign is moderate or repeats, the safest move is to pause the medication and contact the clinic for next steps rather than “pushing through.”