Some dogs have sensitive stomachs, and any new supplement can be the thing that tips them into soft stool, gassiness, or a picky appetite. With MSM powder for dogs, the simplest way to reduce friction is to start low, mix thoroughly into food, and keep the rest of the day steady—same meals, same treats, same schedule. That makes it easier to tell what’s helping and what’s not.
If your dog has a history of digestive disease, is on multiple medications, or is recovering from illness, your veterinarian should guide whether MSM fits at all and how to introduce it safely (Horváth K, 2002). Comfort should look calm and uncomplicated: normal stool, normal appetite, and a dog who seems unbothered by the routine.