5 Coat Warning Signs of Illness in Dogs & Cats
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References
Numbered references identify the sources used for specific claims. Read the study design, species and evidence boundaries alongside each finding.
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Agency for Toxic Substances and Disease Registry. ToxGuide for Silica. Study design/context: Toxicology guidanceSpecies/context: Human exposure; experimental animalsEvidence boundary: Distinguishes chemical structure and exposure routes.↩ 1 · ↩ 2 · ↩ 3 · ↩ 4
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US Food and Drug Administration. 21 CFR § 573.940 — Silicon dioxide. Study design/context: Animal-feed regulationSpecies/context: Animal feedEvidence boundary: Permits specified technical uses; the complete-feed ceiling is not a cat dose.↩ 1 · ↩ 2
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Supannee Sripanyakorn and colleagues. The comparative absorption of silicon from different foods and food supplements. Study design/context: Human absorption studiesSpecies/context: HumansEvidence boundary: Compared dissolution and blood/urine silicon after different preparations.↩ 1 · ↩ 2 · ↩ 3 · ↩ 4
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Karen A. Moriello. Structure of the Skin in Cats. Study design/context: Veterinary anatomy referenceSpecies/context: CatsEvidence boundary: Describes skin layers, collagen, glands and hair growth.↩ 1 · ↩ 2 · ↩ 3 · ↩ 4
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D. M. Reffitt and colleagues. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Study design/context: Cell experimentsSpecies/context: Human osteoblast-like cellsEvidence boundary: A soluble silicon preparation increased collagen synthesis in cultured cells.↩ 1 · ↩ 2 · ↩ 3 · ↩ 4
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A. Barel and colleagues. Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin. Study design/context: Randomized placebo-controlled trialSpecies/context: WomenEvidence boundary: Measured skin roughness and self-rated hair and nail brittleness.↩ 1 · ↩ 2 · ↩ 3
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R. R. Wickett and colleagues. Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in women with fine hair. Study design/context: Randomized placebo-controlled trialSpecies/context: WomenEvidence boundary: Measured hair mechanics and dimensions over nine months.↩ 1 · ↩ 2 · ↩ 3 · ↩ 4 · ↩ 5
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FEDIAF. Nutritional Guidelines for Complete and Complementary Pet Food for Cats and Dogs. Study design/context: Complete-food recommendationsSpecies/context: Cats and dogsEvidence boundary: The feline nutrient table does not establish a silica minimum.↩ 1 · ↩ 2 · ↩ 3
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Cornell Feline Health Center. Feeding Your Cat. Study design/context: Veterinary nutrition guidanceSpecies/context: CatsEvidence boundary: Complete food and life-stage nutrition.↩ 1 · ↩ 2
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La Petite Labs. Pet Gala ingredient guide. Study design/context: Ingredient declarationsSpecies/context: Dogs and catsEvidence boundary: Current silica entry and the broader formula.↩ 1 · ↩ 2 · ↩ 3 · ↩ 4
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Fumihito Takahashi and colleagues. The Silicon Concentration in Cat Urine and Its Relationship with Other Elements. Study design/context: Observational urine comparisonSpecies/context: CatsEvidence boundary: Ten cats with non-silica stones and fifteen apparently healthy cats.↩ 1 · ↩ 2
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Lucy Kopecny and colleagues. Urolithiasis in cats: Evaluation of trends in urolith composition and risk factors (2005–2018). Study design/context: Retrospective stone analysisSpecies/context: CatsEvidence boundary: Frequency within submitted stones; no supplement intervention.↩ 1 · ↩ 2
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Malcolm Weir and colleagues. Coat and Skin Appearance in the Healthy Cat. Study design/context: Veterinary coat-care guidanceSpecies/context: CatsEvidence boundary: Nutrition, grooming and other influences on coat appearance.↩ 1 · ↩ 2
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Cornell Feline Health Center. Cats that Lick Too Much. Study design/context: Veterinary owner guidanceSpecies/context: CatsEvidence boundary: Medical causes of excessive licking and hair loss.↩ 1 · ↩ 2
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Yukiko Mizutani and colleagues. Ceramide biosynthesis in keratinocyte and its role in skin function. Study design/context: Mechanistic reviewSpecies/context: Mammalian skinEvidence boundary: Ceramides participate in the barrier limiting water loss.↩
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ASPCA Animal Poison Control Center. Learn More About Silica Gel, A Common Pet Toxin. Study design/context: Poison-control guidanceSpecies/context: PetsEvidence boundary: Accidental drying-packet ingestion and swallowed packaging.↩ 1 · ↩ 2
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Allison Collier. Malabsorption Syndromes in Small Animals. Study design/context: Normal digestive physiologySpecies/context: Dogs and catsEvidence boundary: Describes protein digestion and intestinal absorption.↩
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Sherry Lynn Sanderson. Nutritional Requirements of Small Animals. Study design/context: Veterinary nutrition referenceSpecies/context: Dogs and catsEvidence boundary: Dietary protein supplies material for growth and maintenance.↩
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