Some antiparasitic drug classes used for mites require extra caution in dogs with MDR1 gene mutations (common in Collies and related herding breeds). MDR1 mutations can change how certain macrocyclic lactones are handled by the body, increasing the risk of neurologic side effects at higher exposures (Geyer, 2012). This does not mean mite treatment is impossible; it means the veterinarian should choose and dose carefully. In a household, breed mix can complicate “treat everyone the same.” Owners should tell the clinic if any dog is a Collie, Australian Shepherd, Shetland Sheepdog, or a mix with those breeds, and whether MDR1 testing has been done. Also share any history of tremors, unusual sedation, or sensitivity to medications. These details help the veterinarian keep the plan effective while staying within a safer threshold.