The 12 Hallmarks of Aging in Dogs, Explained
Read full insightQuercetin for Cats
By La Petite Labs Editorial 16 min read
References
Numbered references identify the sources used for specific claims. Read the study design, species and evidence boundaries alongside each finding.
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Zuyi Weng, Bodi Zhang, Shahrzad Asadi, Nikolaos Sismanopoulos, Alan Butcher, Xueyan Fu, Alexandra Katsarou-Katsari, Christina Antoniou, Theoharis C. Theoharides. Quercetin Is More Effective than Cromolyn in Blocking Human Mast Cell Cytokine Release and Inhibits Contact Dermatitis and Photosensitivity in Humans. Study design/context: Human mast-cell laboratory experiments and two open-label human skin pilot studiesSpecies/context: humanEvidence boundary: The cell experiments and human pilots do not establish an oral allergy treatment or dose for cats.↩ 1 · ↩ 2 · ↩ 3
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Tunahan Carpan, Ilayda Tendar, Tahir Ozalp, Songül Erdogan, Hasan Erdoğan, Kerem Ural. Investigation of the Clinical Efficacy of Quercetin in Feline Atopic Dermatitis Syndrome. Study design/context: Fourteen-day before-and-after study in affected cats with a treated healthy comparison groupSpecies/context: catEvidence boundary: All affected cats received quercetin, so the study cannot separate its effect from changes that would have occurred without treatment.↩ 1 · ↩ 2 · ↩ 3
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Motoo Kobayashi, Yuki Okada, Hiromichi Ueno, Takayuki Mizorogi, Kenji Ohara, Koh Kawasumi, Kohei Suruga, Kazunari Kadokura, Yasuyuki Ohnishi, Toshiro Arai. Effects of Supplementation with Anti-Inflammatory Compound Extracted from Herbs in Healthy and Obese Cats. Study design/context: Four-week exploratory supplement study in healthy and obese catsSpecies/context: catEvidence boundary: The study tested a six-herb extract containing a quercetin derivative; findings cannot be assigned to plain quercetin or a different blend.↩ 1 · ↩ 2
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Stephen D. White, Karen A. Moriello. Allergies of Cats. Study design/context: Veterinary clinical guidanceSpecies/context: catEvidence boundary: This guidance describes allergy diagnosis and management; it does not test quercetin.↩ 1 · ↩ 2
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Cornell Feline Health Center. Feline Lower Urinary Tract Disease. Study design/context: University veterinary owner guidanceSpecies/context: catEvidence boundary: Different causes of urinary signs need different treatment; the resource does not report a quercetin trial.↩ 1 · ↩ 2
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Chung-Ping Yu, Ping-Ping Wu, Yu-Chi Hou, Shiuan-Pey Lin, Shang-Yuan Tsai, Chiung-Tong Chen, Pei-Dawn Lee Chao. Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP3A4. Study design/context: Rat pharmacokinetic experiment with supporting laboratory workSpecies/context: ratEvidence boundary: This interaction was observed in rats; its size and clinical consequences cannot be transferred to cats.↩
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Lauren R. Forsythe, Rania Gollakner. Cyclosporine Oral. Study design/context: Veterinary medication guidanceSpecies/context: dog, catEvidence boundary: The medicine guidance supports professional review of supplements; it does not document a feline quercetin interaction trial.↩
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N. E. Lisova, M. I. Zhyla, N. V. Shkodyak, A. V. Rozumniuk, O. P. Laptiy. Study of Tolerance of Drug Based on Quartzetin on Clinically Healthy Cats. Study design/context: Thirty-day tolerability study in healthy catsSpecies/context: catEvidence boundary: The published abstract reports tolerability of one preparation in healthy cats; it does not establish lifetime safety or use with chronic illness.↩
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Pauline A. L. Kosmal, Ryan N. Dilger, Laura Bauer, Jennifer Saunders-Blades, Anna K. Shoveller. A "berry" small inclusion: 40 types of commercial dog and cat kibble with added blueberries provide low levels of quercetin, free phenolics, and alkali-labile phenolics. Study design/context: Laboratory analysis of 40 kibble productsSpecies/context: dog and cat foodsEvidence boundary: The study measured food composition, not nutritional deficiency, allergy response or a supplement benefit.↩
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Cristine Hayes. Garlic and Onion (Allium spp) Toxicosis in Animals. Study design/context: Veterinary toxicology guidanceSpecies/context: cat, dogEvidence boundary: The toxic effects described concern Allium foods and preparations, rather than a test of isolated quercetin.↩
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U.S. Food and Drug Administration. “Complete and Balanced” Pet Food. Study design/context: Government pet-food guidanceSpecies/context: dog, catEvidence boundary: Nutritional adequacy describes the complete diet for its intended life stage; it does not prove benefit from an extra botanical.↩
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U.S. Food and Drug Administration. Proper Storage of Pet Food & Treats. Study design/context: Government pet-product handling guidanceSpecies/context: dog, catEvidence boundary: The guidance addresses suspected food or treat problems; it does not establish quercetin-specific side-effect frequencies.↩
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Carlos Escande, Veronica Nin, Nathan L. Price, Verena Capellini, Ana P. Gomes, Maria Thereza Barbosa, Luke O’Neil, Thomas A. White, David A. Sinclair, Eduardo N. Chini. Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome. Study design/context: Recombinant human CD38 assays and human/mouse cell experiments; separate apigenin mouse experimentSpecies/context: human cells, mouse cells, mouseEvidence boundary: Quercetin findings are enzyme and cell experiments. The in-vivo mouse intervention used apigenin; neither is a cat or Hollywood Elixir trial.↩ 1 · ↩ 2
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Chuan Li, Wei-Jian Zhang, Jaewoo Choi, Balz Frei. Quercetin affects glutathione levels and redox ratio in human aortic endothelial cells not through oxidation but formation and cellular export of quercetin-glutathione conjugates and upregulation of glutamate-cysteine ligase. Study design/context: Human aortic endothelial-cell experimentsSpecies/context: human cellsEvidence boundary: Human-cell findings about glutathione regulation; not a feline supplement trial or evidence of a finished-formula effect.↩ 1 · ↩ 2
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Rachel S. Fletcher, Joanna Ratajczak, Craig L. Doig, Lucy A. Oakey, Rebecca Callingham, Gabriella Da Silva Xavier, Antje Garten, Yasir S. Elhassan, Philip Redpath, Marie E. Migaud, Andrew Philp, Charles Brenner, Carles Canto, Gareth G. Lavery. Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells. Study design/context: Mechanistic pathway study using mouse muscle cells and genetic modelsSpecies/context: mouse, mouse cellsEvidence boundary: Supports the NAD precursor pathway and ordinary cellular energy biology; no dog or cat supplement efficacy inferred.↩ 1 · ↩ 2
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Reactome. Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2. Study design/context: Curated human respiratory-chain reactionSpecies/context: human biochemical pathwayEvidence boundary: Curated biochemical reaction, not a supplementation or finished-formula trial.↩
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Reactome. GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+. Study design/context: Curated biochemical reactionSpecies/context: human biochemical pathwayEvidence boundary: Glutathione recycling uses NADPH; this reaction does not establish an oral quercetin effect in cats.↩
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