Safety data for NR is stronger in humans and laboratory models than it is in cats, so a conservative, monitoring-first approach is appropriate (Mehmel, 2020). The most practical early watch-outs are gastrointestinal: loose stool, vomiting, gas, or general GI upset. Some cats may also show appetite changes (reduced interest in food or, less commonly, increased hunger). Any persistent GI signs, dehydration risk, or refusal to eat warrants pausing the supplement and contacting a veterinarian.
Cats with kidney or liver comorbidities deserve extra caution. These conditions can change how nutrients and metabolites are processed and may also narrow the margin for tolerating appetite disruption or dehydration. A medication review matters as well: before starting NR, confirm with your vet that it fits alongside the cat’s current prescriptions and supplements, especially if the cat is on multiple drugs or has chronic disease monitoring.
Stop and contact your veterinarian promptly if you notice repeated vomiting, marked lethargy, worsening appetite, diarrhea lasting more than a day, signs of abdominal pain, or any sudden change in drinking/urination patterns. In cats, “wait and see” can become risky quickly when hydration and caloric intake drop.