Not every dog is a good candidate for every supplement. Puppies, pregnant or nursing dogs, dogs with chronic kidney or liver disease, and dogs on multiple medications deserve extra caution. NSAID use, in particular, should prompt a careful discussion about side effects and monitoring (Gassner G, 1998).
A safe approach to inflammation resolution for dogs is simple: introduce one change at a time, keep a short log, and stop if you see vomiting, diarrhea, appetite loss, or unusual lethargy. Your veterinarian can help you decide whether the issue is the product, the dose, the timing, or an unrelated health change that surfaced at the same moment.