The 12 Hallmarks of Aging in Dogs, Explained
Read full insightVitamin B for Dogs
17 science-backed actives
Contents
References
Numbered references identify the sources used for specific claims. Read the study design, species and evidence boundaries alongside each finding.
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U.S. Food and Drug Administration. “Complete and Balanced” Pet Food. Evidence boundary: Nutritional adequacy statements, life stages and the purpose of complete pet food.↩ 1 · ↩ 2 · ↩ 3
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NIH Office of Dietary Supplements. Thiamin—Fact Sheet for Health Professionals. Evidence boundary: Thiamin’s normal coenzyme role in nutrient metabolism.↩
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Reactome. Vitamin B2 (riboflavin) metabolism. Evidence boundary: Riboflavin-derived cofactors in normal energy reactions.↩ 1 · ↩ 2 · ↩ 3
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NIH Office of Dietary Supplements. Vitamin B6—Fact Sheet for Health Professionals. Evidence boundary: Normal B6 biochemistry, including amino-acid and neurotransmitter metabolism.↩ 1 · ↩ 2 · ↩ 3
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Texas A&M University Gastrointestinal Laboratory. Cobalamin (Vitamin B12) and Folate. Evidence boundary: Clinical context for B12 and folate testing, including malabsorption and normal-test limitations.↩ 1 · ↩ 2 · ↩ 3
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Chang CH, Lidbury JA, Suchodolski JS, Steiner JM. Effect of oral or injectable supplementation with cobalamin in dogs with hypocobalaminemia caused by chronic enteropathy or exocrine pancreatic insufficiency. Evidence boundary: Randomized oral-versus-injectable cyanocobalamin treatment in dogs with low B12 and chronic enteropathy or EPI.↩ 1 · ↩ 2 · ↩ 3
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Verena Habermaass, Aurora Cogozzo, Francesco Bartoli, Valentina Vitelli, Rebecca Dini, Veronica Marchetti. Water-Soluble Vitamins (Riboflavin, Niacin, Pantothenic Acid) in Dogs with Chronic Liver Disease vs. Healthy Controls. Evidence boundary: An observational comparison of B2, B3 and B5 in dogs with chronic liver disease and healthy controls.↩ 1 · ↩ 2
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G. Krinke, H. H. Schaumburg, P. S. Spencer, J. Suter, P. Thomann, R. Hess. Pyridoxine megavitaminosis produces degeneration of peripheral sensory neurons (sensory neuronopathy) in the dog. Evidence boundary: Sensory nerve injury after experimental high-dose pyridoxine exposure in dogs.↩
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U.S. Food and Drug Administration. Paws Off Xylitol; It's Dangerous for Dogs. Evidence boundary: Xylitol-containing products and urgent advice after suspected canine ingestion.↩
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Debra Horwitz; Gary Landsberg. Dog Behavior Problems - Coprophagia. Evidence boundary: Behavioural and medical contexts for stool eating, plus practical management.↩
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Fletcher RS et al. Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells. Evidence boundary: NR-to-NAD pathways investigated in mouse and muscle-cell models, with background on normal NAD biology.↩ 1 · ↩ 2 · ↩ 3
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Reactome. Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2. Evidence boundary: The mitochondrial reaction linking NADH, flavin and CoQ electron transfer.↩
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Reactome. GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+. Evidence boundary: Glutathione regeneration using NADPH in a curated biochemical pathway.↩
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Cline JL, Odle J, Easter RA. The riboflavin requirement of adult dogs at maintenance is greater than previous estimates. Evidence boundary: A controlled riboflavin feeding experiment assessing a biochemical requirement in adult dogs.↩ 1 · ↩ 2
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