These sources informed the rubric criteria, scoring tier definitions, and methodology disclosure. All references are publicly accessible.
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[1]
Lifespan and Healthspan: Past, Present, and Promise.
Eileen M Crimmins ·link.springer.com ·2015
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[2]
A masked, placebo-controlled, randomized clinical trial evaluating safety and the effect on cardiac function of low-dose rapamycin in 17 healthy client-owned dogs.
Barnett BG, Wesselowski SR, Gordon SG, Saunders AB, Promislow DEL, Schwartz SM, Chou L, Evans JB, Kaeberlein M, Creevy KE ·pubmed.ncbi.nlm.nih.gov ·2023
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[3]
Enhancing cognitive functions in aged dogs and cats: a systematic review of enriched diets and nutraceuticals.
Blanchard T, Eppe J, Mugnier A, Delfour F, Meynadier A ·pubmed.ncbi.nlm.nih.gov ·2025
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[4]
Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project.
Coleman AE, Creevy KE, Anderson R, Reed MJ, Fajt VR, Aicher KM, Atiee G, Barnett BG, Baumwart RD, Boudreau B, Cunningham SM, Dunbar MD, Ditzler B, Ferguson AM, Forsyth KK, Gambino AN, Gordon SG, Hammond HK, Holland SN, Iannaccone MK, Illing K, Kadotani S, Knowles SA, MacLean EL, Maran BA, Markovic LE, McGrath S, Melvin RL, Mueller MS, Nelson OL, Olby NJ, Pancotto TE, Parsley E, Potter BM, Prescott JO, Saunders AB, Sawyer HM, Scansen BA, Schmid SM, Smith CC, Tjostheim SS, Tolbert MK, Tropf MA, Visser LC, Ward JL, Wesselowski SR, Windsor RC, Yang VK, Ruple A, Promislow DEL, Kaeberlein M, Dog Aging Project Consortium ·pubmed.ncbi.nlm.nih.gov ·2025
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[5]
Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs.
Paoloni MC, Mazcko C, Fox E, Fan T, Lana S, Kisseberth W, Vail DM, Nuckolls K, Osborne T, Yalkowsy S, Gustafson D, Yu Y, Cao L, Khanna C ·pmc.ncbi.nlm.nih.gov ·2010
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[6]
Use of pimobendan in cats: a practical evidence-based review.
Gordon SG, Saunders AB, Wesselowski S, Malcolm EL, Watson A ·pmc.ncbi.nlm.nih.gov ·2025
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[7]
Effects of rapamycin in experimental organ allografting.
Ochiai T, Gunji Y, Nagata M, Komori A, Asano T, Isono K ·pubmed.ncbi.nlm.nih.gov ·1993
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[8]
Pharmacokinetics and pharmacodynamics of suberoylanilide hydroxamic acid in cats.
McDonnel SJ, Tell LA, Murphy BG ·pmc.ncbi.nlm.nih.gov ·2014
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[9]
Urolithin A improves motility, antioxidant defense, and mitochondrial function of chilled canine spermatozoa during 72-h liquid storage.
Mirzaei R, Soleimanzadeh A, Asri-Rezaei S ·pubmed.ncbi.nlm.nih.gov ·2026
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[10]
Nicotinamide Riboside-The Current State of Research and Therapeutic Uses.
Mehmel M, Jovanović N, Spitz U ·pmc.ncbi.nlm.nih.gov ·2020
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[11]
Veterinary Adverse Event Reporting for Manufacturers
fda.gov ·2025
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[12]
“Complete and Balanced” Pet Food
fda.gov ·2023